Heart: Hypertension in the Elderly - Too Little, Too Late

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Hypertension in the Elderly: Too Little, Too Late

Abbas Ali, M.D.

Dr. Ali is a Fellow, Geriatrics Division, Saint Louis University School of Medicine, St. Louis, MO. Dr. Ali reports no conflict of interest.

Hypertension (high blood pressure) is a deadly disease that is especially common in the elderly. Over time, abnormally high blood pressure damages the heart and kidneys and increases the risk of stroke, aneurysm and heart attack. Virtually symptomless, hypertension often goes untreated or undertreated. What do doctors know about it and what can be done to treat high blood pressure?

Doctors do know that hypertension becomes more common with age; over 50% of those over 65 have it. In the elderly, hypertension typically takes the form of high systolic blood pressure (SBP), low diastolic blood pressure (DBP) and orthostatic hypotension. Blood pressure readings are expressed by two numbers separated by a slash, e.g., 120/80. The first number is the systolic blood pressure and the second is the diastolic; orthostatic hypotension is an excessive drop in blood pressure when a person stands up; this causes fainting and dizziness.¹

While all of these conditions are fairly treatable, the reality is that treatment of hypertension in the elderly today leaves much to be desired.^2,3, Any older person making health care decisions or anyone who is caring for an older person should educate themselves about hypertension, and raise the issue with their doctor or other health care professional.⁴

The Right Way to Take Blood Pressure
Diagnosing hypertension starts with measuring the blood pressure. Taking blood pressure is a simple thing, but it is often done incorrectly. First of all, it is important that the sphygmomanometer, the familiar instrument with a black rubber cuff that is used to take blood pressure, be the right size. Cuffs that are too small for a particular person's arm may give falsely high readings.⁵

Second, someone who is about to have their blood pressure taken should avoid food, exercise, caffeine and smoking one hour before BP measurement.⁶ Smoking two cigarettes will temporarily raise BP by 10/8 mm Hg for 15 minutes. Drinking a cup of coffee will elevate BP by up to 10/7 mm Hg for from one to two hours.⁷ The patient should sit in a warm room for at least five minutes with their arm supported at the level of the heart. Letting the arm hang will elevate SBP by 10 mm Hg because of the effects of gravity.^8,9

Finally, BP should be checked in both arms; the arm with the higher reading should be used for later readings.¹⁰

What's pseudohypertension?
Pseudohypertension is the appearance of high blood pressure in someone who, in fact, does not have it. One common cause of false high blood pressure readings occurs because compression of the brachial artery in the arm, which is common in the elderly, requires using a higher cuff pressure when taking blood pressure. This will produce systolic and diastolic pressure readings that are 10 mm Hg too high or higher.¹¹

The Major Risk Factors for Hypertension
Medical researchers have identified factors that increase your risk of having high blood pressure:

High salt diet -- the relation between hypertension, diet and salt intake was demonstrated by a famous study called the DASH low sodium trial. Reduction of salt intake combined with a dietary regimen called DASH (Dietary Approaches to Stop Hypertension) successfully helped many to lower their blood pressure.¹²
High alcohol intake¹³
Family history of hypertension
Obesity -- the risk of hypertension for moderately obese men is two times higher than men who are not obese.¹⁴
African-American heritage -- hypertension is more common and more severe in African-Americans than in otherAmericans.¹⁵

Diagnosing Hypertension
The United States Preventive Service Task Force (USPSTF) recommends that blood pressure be taken at each medical visit for anyone over 21. This should include assessing risk factors for cardiovascular disease and counseling about life style changes such as increasing physical activity, lowering alcohol consumption and smoking, as well as eating a healthier diet.

It is important that your doctor measure your blood pressure more than once. Studies have shown that as many as 25% of all people -- even more among the elderly -- who appear to exhibit mild hypertension at the physician's office, may in fact be suffering from medical office examination anxiety, or "white coat hypertension."¹⁶ To avoid falsely labeling such patients as hypertensives, sometimes your doctor may suggest that a nurse check your BP at home or ask you to check your own BP at home.

The Health Effects of Hypertension
Atherosclerosis and coronary artery disease (CAD) are strongly associated with hypertension.^17,18,19 Hypertension is the most common risk factor for congestive heart failure (CHF).²⁰ In hypertensives, the risk of CHF is two times higher than normal in men and three times higher in women. In a study of people aged 40 to 89 who were followed for 20.1 years, 91% of those who developed CHF had a history of hypertension. In the study, those with hypertensive CHF did not live long; only 24% of the men and 31% of the women survived five years.^21,22

Stroke is another very serious complication of hypertension. A study called the Systolic Hypertension Trial in Europe (Syst-Eur) showed that aggressive treatment of hypertension reduces the risk of stroke by 42%.²³ According to the Melbourne Risk Factor Study, hypertension is the most important risk factor for intracerebral hemorrhage.^24,25

The Syst-Eur trial also demonstrated a link between dementia and systolic hypertension.²⁶ These findings indicate that if 1000 people with systolic hypertension were treated for 5 years, 19 cases of dementia might be prevented.

Treatment
Many trials have confirmed the obvious -- that the elderly benefit from effective treatment of hypertension.^{27,28,29,30,31} Successful treatment reduces total mortality by 13%, cardiovascular mortality by 18%, all cardiovascular complications by 26%, stroke by 30% and coronary events by 23%.

Unfortunately, however, these same studies also show that hypertension in the elderly is undertreated. In one study, in the case of elderly people who visited the doctor with hypertension that was documented for at least six months -- a clear indication that treatment is needed -- doctors started or changed treatment for hypertension only 38% of the time.

"Goal BP" and the Elderly
There is no ideal blood pressure that is right for all people at all ages. Your doctor must still decide what goal blood pressure best suits you and how best to achieve it. Life style modification should be tried first.^32,33 Salt should be restricted to 2.3 g or 6 g of table salt per day.

Although dietary restrictions can be helpful, they need to be used with care in the elderly because appetite declines with age, and salt restriction can lead to weight loss, which can create further blood pressure complications.³⁴

While moderate alcohol intake (one or two drinks per day) is good for the heart and the cardiovascular system generally,³⁵ alcohol consumption of more than two drinks per day can cause or worsen hypertension.³⁶

Is There a Drug of Choice?
Drugs are the primary weapon used today to fight hypertension. Particularly in the elderly, drug therapy for hypertension should be gentle, starting low and going slow, with care to avoid drugs that may cause hypotension (low blood pressure).

The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)³⁷ suggests that low dose thiazide diuretics have a better cardiovascular protective effect than the newer ACE inhibitors (ACEIs) and calcium channel blockers in patients with risk factors for coronary artery disease, diabetes, previous heart attack, stroke, hyperlipidemia, cigarette smoking or other atherosclerotic cardiovascular disease.

The following drugs may also be prescribed in certain situations:

Angiotensin converting enzyme inhibitors (ACEIs) are preferable for those with heart failure, chronic renal failure (CRF) and for type 1 diabetics with kidney disease.^38,39,40
Angiotensin receptor blockers (ARBs) are effective in those who cannot tolerate ACE inhibitors, in severe hypertension with enlarged heart, and in patients who have type 2 diabetes and who are spilling protein into their urine.⁴¹
Beta blockers are preferred for those who have had a heart attack because of their positive effect on heart rhythm. They are also beneficial in patients with heart failure.⁴² Given that many of the elderly are on fixed incomes, it is important to note that beta blockers are relatively inexpensive.
Calcium channel blockers (CCBs) are often used for those with angina and conditions that make it difficult for patients to tolerate other drugs.

For certain special circumstances, doctors may prescribe a number of other drugs.^{43,44,45,46,47,48}

The Future
While we know much about the treatment of high blood pressure in the elderly, we need to know more. New studies are now on-going which will eventually help doctors better manage hypertension in the elderly. Meanwhile, the best treatment for the hypertensive elderly remains using proper techniques of blood pressure measurement, making the appropriate life style changes, and selecting the right drug or drugs for a particular patient.⁴⁹

October 2004

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References
1. Franklin SS, Gustun W 4th, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D. Hemodynamic patterns of age related changes in blood pressure. The Framingham Study. Circulation 1997 Jul 1;96 (1): 308-15).return

2. The Sixth Report OF The Joint National Committee on Detection, Evaluation, and Diagnosis of High Blood Pressure (JNC-V1). Arch Intern Med 1997; 157:2413. return

3. Oliveria, SA, Lapuerta, P, McCarthy, BD, et al. Physician-related barriers to the effective management of uncontrolled hypertension. Arch Intern Med 2002; 162: 413. return

4. Hyman DJ, Pavlik, VN. Characteristics of Patients with Uncontrolled Hypertension in the United States. NEJM, 345:479-486. return

5. Recommendations for routine blood pressure measurement by indirect cuff sphygmomanometry. American Society of Hypertension. Am J Hypertens 1992; 5:207. return

6. Beevers G, Lip GY, O'Brien E. ABC of hypertension. Blood pressure measurement. Part 1. Sphygmomanometry: Factors common in all techniques. BMJ 2001; 322:981. return

7. Freestone S, Ramsay LE. Effect of coffee and cigarette smoking on the blood pressure of untreated and diuretic treated hypertensive patients. Am J Med 1982 Sep; 73(3):348-53. return

8. Beevers G, Lip GY, O'Brien, E. ABC of hypertension. Blood pressure measurement. Part 2. Conventional sphygmomanometry: Technique of auscultatory blood pressure measurement. BMJ. 2001; 322: 1043. return

9. Cavallini MC,Roman MJ,Blank SG, et al. Association of the auscultatory gap with vascular disease in hypertensive patients. Ann Intern Med 1996;9:124:877. return

10. Gosse P. Blood pressure should be measured in both arms on the first consultation. J Hypertens 2002;20:1045. return

11. Zweifler AJ, Shahab ST. Pseudohypertension: A new assessment. J Hypertens 1993;11:1. return

12. Sacks FM, Svetkey LP, Vollmer WM, et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. NEJM 2001;344:3-10. return

13. Klatky AL, Friedman GD, Siegelaub AA, Gerard MJ. Alcohol consumption and blood pressure. Kaiser-Permanente Multiphasic Health Examination data. NEJM 1977; 296: 1194. return

14. Thompson D, Edelsberg J, Colditz GA, et al. Lifetime health and economic consequences of obesity. Arch Intern Med 1999;159:2177. return

15. Cooper RS, Kaufman JS. Race and hypertension. Hypertension 1998;32:813. return

16. Pickering TG, James GD, Boddie C, et al. How common is white coat hypertension? JAMA 1988; 259:225. return

17. Thomas G. Pickering, Jon D. Blumenfeld, John H. Laragh. Brenner and Rector's, The Kidney, vol 2, Fifth Edition:2110-2111. return

18. Wilson PW. Established risk factors and coronary artery disease: The Framingham Study. Am J Hypertens 1994;7:7S. return

19. Lewington S, Clarke R, Qizilbash N, et al. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360:1903. return

20. Levy D, Larson MG, Vasan RS, et al. The progression from hypertension to congestive heart failure. JAMA 1996;275:1557. return

21. Lorell BH, Carabello BA. Left ventricular hypertrophy. Pathogenesis, detection, and prognosis. Circulation 2000; 102:470. return

22. Vakili BA, Okin PM, Devereux RB. Prognostic implications of left ventricular hypertrophy. Am Heart J 2001;141:334. return

23. Staessen JA, Fagard R, Thijs L, et al. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet 1997; 350:757. return

24. Thrift AG, McNeil JJ, Forbes A, et al. Risk factors for cerebral hemorrhage in the era of well controlled hypertension. Melbourne Risk Factor Study (MERFS) Group. Stroke 1996;27:2020. return

25. Coresh J, Wei L, McQuillan G,et al. Prevalence of high blood pressure and elevated serum creatinine level in the United States. Findings from the third National Health and Nutrition Examination Survey (1988-1994). return

26. Forette F, Seux ML, Staessen JA, et al. Prevention of dementia in randomized double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur)Trial. Lancet 1997;350:757. return

27. Medical Research Council Trial of treatment of hypertension in older adults: principal results. MRC Working Party. BMJ 1992;304:405. return

28. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA 1991;265:3255. return

29. Dahlof B, Lindholm LH , Hansson L, et al. Morbidity and Mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension). Lancet 1991;338:1281. return

30. Staessen JA. Gasowski J. Wang JG. et al. Risks of untreated and treated isolated hypertension systolic hypertension in the elderly: Meta analysis of outcome trials. Lancet 2000; 355:865. return

31. Wang JG, Staessen JA. Antihypertensive drug therapy in older patients. Current Opinion Nephrology and Hypertension 2001;10:263. return

32. Whelton PK, Appel LJ, Espeland MA, et al. Sodium reduction and weight loss in the treatment of hypertension in older persons. A randomized controlled trial of nonpharmachologic intervensions in the elderly(TONE). JAMA 1998;279:839. return

33. Appel L J, Espeland MA, Easter L, Wilson AC. Effects of reduced sodium intake on hypertension control in older individuals: Results from the trial of nonpharmachologic intervensions in the elderly(TONE). Arch Intern Med 2001; 161:685. return

34. Morley JE .Decreased food intake with age. J Gerentol A Biol Sci 2001;56:81. return

35. Palmer AJ, Fletcher AE, Bulpit CJ, et al. Alcohol intake and cardiovascular mortality in hypertensive patients: Report from the department of Health Hypertension Care Computing Project. J Hyperten 1995;13:957. return

36. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood pressure. The JNC 7 report. JAMA 2003;289:2560. return

37. The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288:2981. return

38. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group. NEJM 1987 Jun 4;316(23):1429-35. return

39. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators. NEJM 1991 Aug 1;325(5):293-302. return

40. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. NEJM 1993 Nov 11;329(20):1456-62. return

41. Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S. The RENAAL Study Investigators: Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy. NEJM 2001 Sep 20;345:861-869. return

42. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 1999 Jun 12;353(9169):2001-7. return

43. Shannon J, Jordan J, Costa F, Robertson RM, Biaggioni I. The Hypertension of autonomic failure and its treatment. Hypertension 1997 Nov; 30(5)1062-7. return

44. Jordan J. Shannon JR. Pohar B, Paranjape SY, Robertson D, Robertson RM, Biaggioni I. Contrasting effects of vasodialators on blood pressure and sodium balance in the hypertension of autonomic failure. J Am Soc Nephrol 1999; Jan 10(1):35-42. return

45. Le Couteur DG, Fisher AA, Davis MW, McLean AJ. Postprandial Systolic Blood Pressure, Responses of Older People in Residential Care: Association with risk of Falling. Gerontology 2003; 49:260-264. return

46. Goodwin JS. Embracing Complexity: A Consideration of Hypertension in the Very Old. Journal of Gerontology: Medical Sciences 2003, Vol 58A,No 7, 653-658. return

47. Mattila K, Haavisto M, Rajala S, Heikinheimo R. Blood pressure and five year survival in the very old. BMJ. 1988;296:887-889. return

48. Boshuizen HC, Izaks GJ, VanBuuren S, Ligthart GJ. Blood pressure and mortality in elderly people aged 85 and older; community based study. BMJ. 1998;316:1780-1784. return

49. Perry HM, Freis ED, Frohlich ED. Department of Veterans Affairs Hypertension Meeting A Proposal for Improved Care. Hypertension.2000; 35: 853-857. return

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