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  Combination DMARDS for Rheumatoid Arthritis

Peter Barland, M.D.

Table 2. Outline of Early Combinations DMARDS Trials.

Drugs* Doses Results Toxicities Refs.
Initial Maximum Duration Imprvmts
SSZ + MTX 7.5mg/wk 2g/d
17.5mg/wk		 52 wks Tend to greater efficacy Equal in all groups 1
SSZ + MTX 2g/d
7.5mg/wk		 3g/d
15mg/wk		 52 wks Tend to greater efficacy Equal in all groups 2
Cyclosporine A + MTX 2mg/kg/d
7.5mg/wk		 3.5mg/kg/d
15mg/wk		 26 wks In joint count
In global score		 Equal in all parts 3
SSZ + MTX+ HCQ 7.5 1g/d
15mg/wk
400mg/d		 2 yrs 77% showed a > 50% response Equal in all parts 4

*All combinations were compared with single agents in randomized, double blinded, prospective trials.



  

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