news search contents meditorial ask the doctor discuss register help home
The Doctor Will See You Now Navigation
Senior LivingWomen's HealthNutritionBioethicsBehaviorSpecialists

The Doctor's Health Tip
Even small amounts of caffeine in some at-risk individuals can precipitate or exaggerate anxiety. more...


  Emerging Treatments: Combination DMARDS for Rheumatoid Arthritis

Peter Barland, M.D.

Table 2. Outline of Early Combinations DMARDS Trials.

Drugs* Doses Results Toxicities Refs.
Initial Maximum Duration Imprvmts
SSZ + MTX 7.5mg/wk 2g/d
17.5mg/wk		 52 wks Tend to greater efficacy Equal in all groups 1
SSZ + MTX 2g/d
7.5mg/wk		 3g/d
15mg/wk		 52 wks Tend to greater efficacy Equal in all groups 2
Cyclosporine A + MTX 2mg/kg/d
7.5mg/wk		 3.5mg/kg/d
15mg/wk		 26 wks In joint count
In global score		 Equal in all parts 3
SSZ + MTX+ HCQ 7.5 1g/d
15mg/wk
400mg/d		 2 yrs 77% showed a > 50% response Equal in all parts 4

*All combinations were compared with single agents in randomized, double blinded, prospective trials.



  

  NEWS   SEARCH   CONTENTS   MEDITORIAL   ASK   DISCUSS   REGISTER   HELP   HOME 

© 2008 interMDnet Corporation. All Rights Reserved.  PRIVACY POLICY